Richard F. Heck Ph.D.
Richard F. Heck Ph.D.
The Nobel Prize in Chemistry 2010
Nobel co-recipients: Ei-ichi Negishi, Akira Suzuki
Photo: Holger Motzkau/Wikimedia Commons
Name: Richard Fred Heck
Birth: 15 August 1931, Springfield, MA, USA
Death: 9 October 2015, Manila, Philippines
Institution: University of Delaware, USA
Award: “for palladium-catalyzed cross couplings in organic synthesis”
Subject: Organic chemistry
Portion of cash: 1/3
Doctoral Advisor: Saul Winstein
Physical organic chemist. Palladium-catalyzed cross-coupling reaction. Sole author – 7 consecutive papers. Heck reaction: important concept, tool for organic and medicinal chemists; fuorescence labeling of DNA bases – sequencing DNA/Genome. Thinner computer screens in future. “Great art in test tube.”
Growing orchids in early teens lead to passion for chemistry.
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Patents
| Publication: | 1/5 |
| Publication No: | US 4175187 A |
| Title: | Process for the preparation of tertiary allylic amines from vinylic halides and olefins |
| Publication Type: | Grant |
| Publication Date: | Nov 20, 1979 |
| Filing Date: | October 24, 1978 |
| Inventors: | Richard F. Heck |
| Assignee: | University of Delaware |
| Abstract: | Carboxylic acid esters or amides are obtained from aryl, heterocyclic, vinylic, ethynylic, and benzylic halides and substituted derivates thereof, by reacting same with an alcohol or primary or secondary amine and carbon monoxide, in the presence of a palladium catalyst and if necessary a tertiary amine at about 20.degree.-150.degree. C and from about a half to about 100 atmospheres pressure. A typical example is the conversion of bromobenzene into n-butyl benzoate at 100.degree. C and one atmosphere of carbon monoxide in the presence of tri-n-butyl-amine and a catalytic amount of PdBr.sub.2 [P(C.sub.6 H.sub.5).sub.3 ].sub.2. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 2/5 |
| Publication No: | US 4128554 A |
| Title: | Process for the preparation of carboxylic acid amides from organic halides |
| Publication Type: | Grant |
| Publication Date: | Dec 5, 1978 |
| Filing Date: | March 10, 1977 |
| Inventors: | Richard F. Heck |
| Assignee: | University of Delaware |
| Abstract: | Carboxylic acid amides are obtained from aryl, heterocyclic, and vinylic halides and substituted derivates thereof, by reacting same with a primary or secondary amine and carbon monoxide, in the presence of a palladium catalyst and if necessry a tertiary amine at about 20.degree.-150.degree. C and from at least a half atmosphere pressure. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 3/5 |
| Publication No: | US 3988358 A |
| Title: | Process for the preparation of aldehydes from organic halides |
| Publication Type: | Grant |
| Publication Date: | Oct 26, 1976 |
| Filing Date: | May 10, 1974 |
| Inventors: | Richard F. Heck |
| Assignee: | University of Delaware |
| Abstract: | Carboxylic acid esters or amides are obtained from aryl, heterocyclic, vinylic, ethynylic, and benzylic halides and substituted derivates thereof, by reacting same with an alcohol or primary or secondary amine and carbon monoxide, in the presence of a palladium catalyst and if necessary a tertiary amine at about 20.degree.-150.degree. C and from about a half to about 100 atmospheres pressure. A typical example is the conversion of bromobenzene into n-butyl benzoate at 100.degree. C and one atmosphere of carbon monoxide in the presence of tri-n-butyl-amine and a catalytic amount of PdBr.sub.2 [P(C.sub.6 H.sub.5).sub.3 ].sub.2. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 4/5 |
| Publication No: | US 3960932 A |
| Title: | Process for the preparation of aldehydes from organic halides |
| Publication Type: | Grant |
| Publication Date: | Jun 1, 1976 |
| Filing Date: | Oct 10, 1974 |
| Inventors: | Richard F. Beck |
| Assignee: | University of Delaware |
| Abstract: | Aldehydes are obtained from aryl, vinylic and heterocyclic halides and substituted derivatives thereof, a tertiary amine, carbon monoxide and hydrogen at from about 50.degree.-175.degree.C under from about one to 200 atmospheres pressure and with PdX.sub.2 [P(C.sub.6 H.sub.5).sub.3 ].sub.1 or 2 as a catalyst where X is acetate or a halogen. The ratios of carbon monoxide to hydrogen are not critical but the most favorable reactions are usually obtained with ratio from about 0.1 to about 10. A typical example is the conversion of p-bromoanisole to anisaldehyde in 84% yield at 150.degree.C in 18 hrs. at 1000 psig. of 1:1 CO to H.sub.2 with one mole percent of PdBr.sub.2 [P(C.sub.6 H.sub.5).sub.3 ].sub.2 as catalyst and with tri-n-butylamine as the tertiary amine. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |
| Publication: | 5/5 |
| Publication No: | DE1134832 B |
| Title: | A process for the polymerization of Vinylalkylaethern translated from German |
| Publication Type: | Applications |
| Publication Date: | Aug 16, 1962 |
| Filing Date: | Sep 12, 1960 |
| Inventors: | Richard Fred Heck, Edwin James Vandenberg, Robert Chiang |
| Assignee: | |
| Abstract: | No Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents USPTO Patent Database |