Robert Merrifield Ph.D.
Robert Merrifield Ph.D.
The Nobel Prize in Chemistry 1984
Photo: Dann Kristoff. Painting: Tim Tompkins PaintHistory,com
Name: Robert Bruce Merrifield
Birth: 15 July 1921, Fort Worth, TX, USA
Death: 14 May 2006, Cresskill, NJ, USA
Institution: Rockefeller University, New York, NY, USA
Award: “for his development of methodology for chemical synthesis on a solid matrix”
Subject: biochemistry
1/1
Award: “for his development of methodology for chemical synthesis on a solid matrix”
Patents
| Publication: | 1/13 |
| Publication No: | US 5714467 A |
| Title: | Antibacterial and antimalarial hybrid peptides |
| Publication Type: | Grant |
| Publication Date: | Feb 3, 1998 |
| Filing Date: | Mar 26, 1993 |
| Inventors: | Hans G. Boman, Robert B. Merrifield, David Andreu |
| Original Assignee: | The Rockefeller University |
| Abstract: | The invention relates to antibacterial and antimalarial peptides which are hybrids peptides which a of naturally occurring peptides such as cecropins, attacins, magainins, sarcotoxin, sapecin, bactenecins, alamethidicins, defensins and PGLa, and toxins such as streptolysins, melittin, barbatolysin, paradaxins and delta hemolysin. The hybrid peptides of the present invention are easily synthesized and have reduced toxicity. Also included in the invention are pharmaceutical compositions containing such hybrid peptides, and methods of treating patients infected with an organism against which these peptides are active. |
| Representative Figure: | No Figure |
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| Details | Google Patents Espacenet |
| Publication: | 2/13 |
| Publication No: | US 5585353 A |
| Title: | Antibiotic peptides containing D-amino acids |
| Publication Type: | Grant |
| Publication Date: | Dec 17, 1996 |
| Filing Date: | Sep 16, 1994 |
| Inventors: | Robert B. Merrifield, David Wade, Hans G. Boman |
| Original Assignee: | The Rockefeller University |
| Abstract: | Antibiotically and/or antimalarially active D-peptides of naturally occurring antibiotics such as cecropin A, B and D, melittin, and Magainin I and II and their addition, deletion and replacement analogs including homologous and heterologous analogs thereof. |
| Representative Figure: | No Figure |
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| Details | Google Patents Espacenet |
| Publication: | 3/13 |
| Publication No: | US 5480867 A |
| Title: | Glucagon analogs with serine replacements |
| Publication Type: | Grant |
| Publication Date: | Jan 2, 1996 |
| Filing Date: | Jun 8, 1994 |
| Inventors: | Robert B. Merrifield, Cecilia G. Unson |
| Original Assignee: | The Rockefeller University |
| Abstract: | Glucagon analogs characterized principally by the removal or replacement of the 9-aspartic acid residue or its replacement with another amino acid residue together with replacement of the 16-serine residue and possible replacement of the 11-serine residue and 21-aspartic acid residue with or without a histidine at the amino terminal are useful adjuncts to insulin therapy. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents Espacenet |
| Publication: | 4/13 |
| Publication No: | US 5258454 A |
| Title: | Peptide synthesis method and solid support for use in the method |
| Publication Type: | Grant |
| Publication Date: | Nov 2, 1993 |
| Filing Date: | May 12, 1992 |
| Inventors: | Rolf H. Berg, Kristoffer Almdal, Walther B. Pedersen, Arne Holm, James P. Tam, Robert B. Merrifield |
| Original Assignee: | Riso National Laboratory |
| Abstract: | A method for the solid-phase synthesis of peptides or proteins in high yield and high purity uses a solid-support consisting of a functionalized polystyrene-grafted polymer substrate, the grafted polystyrene chains being substantially non-cross-linked and having a chain molecular weight, not including optional non-reactive substituents, of at least 200,000, preferably in the range of 600,000-1,200,000. Particularly suitable polymer substrates are substrates of a polyolefin such as polyethylene. The method is particularly well-suited to the compartmentalized synthesis of a multitude of peptides or proteins in a parallel and substantially simultaneous fashion. Preferred embodiments of a solid support for performing the synthesis are prepared from thin polyethylene sheet or film which has been grafted with polystyrene chains in a radical-initiated process in which the polyethylene sheet or film is immersed in a solution of optionally substituted styrene monomer in an alcohol such as methanol, the volume percentage of styrene in the solution preferably being about 30% v/v, and subjected to gamma irradiation. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents Espacenet |
| Publication: | 5/13 |
| Publication No: | US 5143902 A |
| Title: | Glucagon analogs with ASP9 replacements or deletions |
| Publication Type: | Grant |
| Publication Date: | Sep 1, 1992 |
| Filing Date: | Dec 16, 1991 |
| Inventors: | Robert B. Merrifield, Cecilia G. Unson |
| Original Assignee: | The Rockefeller University |
| Abstract: | Glucagon analogs characterized principally by the removal of the 9-aspartic acid residue or its replacement with an amino acid residue other than an L- dibasic amino acid containing up to five carbon atoms with or without a histidine at the amino terminal are useful adjuncts to insulin therapy. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents Espacenet |
| Publication: | 6/13 |
| Publication No: | US 4879273 A |
| Title: | Glucagon homologs and therapeutic use thereof |
| Publication Type: | Grant |
| Publication Date: | Nov 7, 1989 |
| Filing Date: | May 22, 1987 |
| Inventors: | Robert B. Merrifield |
| Original Assignee: | The Rockefeller University |
| Abstract: | Glucagon analogs characterized principally by deletion of the number one histidine and replacement of the number nine aspartic acid with glutamic acid are useful adjuncts to insulin therapy. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents Espacenet |
| Publication: | 7/13 |
| Publication No: | US 4560676 A |
| Title: | N.sup.α -desacetylthymosinα1 and process |
| Publication Type: | Grant |
| Publication Date: | Dec 24, 1985 |
| Filing Date: | Apr 13, 1981 |
| Inventors: | Robert B. Merrifield |
| Original Assignee: | The Rockefeller University |
| Abstract: | The preparation of N.sup.α -desacetylthymosinα1 and its use as a hormonally active agent participating in the regulation, differentiation and function of thymic dependent lymphocytes (T-cells) is described. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents Espacenet |
| Publication: | 8/13 |
| Publication No: | US 4507230 A |
| Title: | Peptide synthesis reagents and method of use |
| Publication Type: | Grant |
| Publication Date: | Mar 26, 1985 |
| Filing Date: | May 12, 1982 |
| Inventors: | James P. Tam, William F. Heath, Jr., Robert B. Merrifield |
| Original Assignee: | Research Corporation |
| Abstract: | A method of releasing a functional group present in an amino acid or amino acyl residue from a resin or protecting residue which is bonded to the functional group by a linkage having proton affinity, which comprises: reacting the functional group bonded to the organic residue, with a mixture of HF and a base for a time and under conditions effective to produce the release; wherein the amounts of HF and base in the mixture are adjusted so that said release occurs substantially by an SN 2 mechanism. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents Espacenet |
| Publication: | 9/13 |
| Publication No: | US 4293455 A |
| Title: | N.sup.α -Desacetylthymosinα1 and process |
| Publication Type: | Grant |
| Publication Date: | Oct 6, 1981 |
| Filing Date: | Apr 7, 1980 |
| Inventors: | Robert B. Merrifield, Tai W. Wong |
| Original Assignee: | Rockefeller University |
| Abstract: | The preparation of N.sup.α -desacetylthymosinα1 and its use as a hormonally active agent participating in the regulation, differentiation and function of thymic dependent lymphocytes (T-cells) is described. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents Espacenet |
| Publication: | 10/13 |
| Publication No: | US 3531258 A |
| Title: | Apparatus for the automated synthesis of peptides |
| Publication Type: | Grant |
| Publication Date: | Sep 29, 1970 |
| Filing Date: | Nov 16, 1967 |
| Inventors: | Nils Jernberg, Robert Bruce Merrifield, John M Stewart |
| Original Assignee: | Us Health Education & Welfare |
| Abstract: | No Abstract |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents Espacenet |
| Publication: | 11/13 |
| Publication No: | WO 9204042 A1 |
| Title: | Glucagon analogs with asp9 replacements or deletions |
| Publication Type: | Grant |
| Publication Date: | Mar 19, 1992 |
| Filing Date: | Aug 8, 1991 |
| Inventors: | Robert Bruce Merrifield, Cecilia G Unson |
| Original Assignee: | Univ Rockefeller |
| Abstract: | Glucagon analogs characterized principally by the removal of the 9-aspartic acid residue or its replacement with an amino acid residue other than an L- dibasic amino acid containing up to five carbon atoms with or without a histidine at the amino terminal are useful adjuncts to insulin therapy. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents Espacenet |
| Publication: | 12/13 |
| Publication No: | WO 9011771 A1 |
| Title: | Antibacterial and antimalarial peptides |
| Publication Type: | Grant |
| Publication Date: | Oct 13, 1990 |
| Filing Date: | Apr 12, 1990 |
| Inventors: | Hans G Boman, Robert Bruce Merrifield |
| Original Assignee: | Univ Rockefeller |
| Abstract: | Antibiotically and/or antimalarially active hybrid peptides containing from about 20 to about 40 amino acid residues are prepared by rearranging selected sequences of known peptides. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents Espacenet |
| Publication: | 13/13 |
| Publication No: | WO 9002749 A1 |
| Title: | Peptide synthesis method and solid support for use in the method |
| Publication Type: | Grant |
| Publication Date: | Mar 22, 1990 |
| Filing Date: | Aug 31, 1989 |
| Inventors: | Rolf H Berg, Kristoffer Almdal, Walther Batsberg Pedersen, Arne Holm, James P Tam, Robert Bruce Merrifield |
| Original Assignee: | Risoe Forskningscenter |
| Abstract: | A method for the solid-phase synthesis of peptides or proteins in high yield and high purity uses a solid support consisting of a functionalized polystyrene-grafted polymer substrate, the grafted polystyrene chains being substantially non-cross-linked and having a chain molecular weight, not including optional non-reactive substituents, of at least 200,000, preferably in the range of 600,000-1,200,000. Particularly suitable polymer substrates are substrates of a polyolefin such as polyethylene. The method is particularly well-suited to the compartmentalized synthesis of a multitude of peptides or proteins in a parallel and substantially simultaneous fashion. Preferred embodiments of a solid support for performing the synthesis are prepared from thin polyethylene sheet or film which has been grafted with polystyrene chains in a radical-initiated process in which the polyethylene sheet or film is immersed in a solution of optionally substituted styrene monomer in an alcohol such as methanol, the volume percentage of styrene in the solution preferably being about 30 % v/v, and subjected to gamma irradiation. |
| Representative Figure: | No Figure |
| Family | |
| Details | Google Patents Espacenet |